Gabriel M, Orona E, Foster K, Lambert R W
J Comp Physiol Psychol. 1980 Dec;94(6):1087-100. doi: 10.1037/h0077739.
Unit activity of the cingulate cortex and the anteroventral (AV) nucleus of the thalamus in rabbits was recorded during reversal training following differential conditioning of a locomotory (wheel rotation) avoidance response. The positive and negative conditional stimuli (CS+ and CS-) were pure tones (1 kHz and 8 kHz), and the unconditional stimulus was footshock (1.5 mA). During the first session, activity appropriate to the original task (i.e., a greater neuronal response to the CS- than to the CS+) occurred in the deep cortical laminae (V and VI), but the superficial laminae (I-IV) manifested the original discrimination in certain records and the reverse discrimination in others. All discriminative effects diminished during subsequent sessions except the short-latency (25-msec) deep laminar original discrimination, which persisted throughout reversal training. Activity of the AV nucleus underwent gradual transition, in parallel with the behavior, from the original to the reverse discrimination. Arousal-producing footshocks given after behavioral reversal educed the original and reverse discriminations in the deep and superficial laminae, respectively. These data are interpreted to indicate the role of cingulate cortex and anterior thalamus for encoding the associative significance of the conditional stimuli.
在对家兔的运动性（轮转动）回避反应进行辨别性条件反射后的反转训练期间，记录了扣带回皮质和丘脑前腹侧（AV）核的单位活动。正性和负性条件刺激（CS+和CS-）为纯音（1千赫和8千赫），非条件刺激为足部电击（1.5毫安）。在第一个实验阶段，在深层皮质板层（V层和VI层）出现了与原始任务相符的活动（即对CS-的神经元反应大于对CS+的反应），但在某些记录中，浅层板层（I-IV层）表现出原始辨别，而在另一些记录中则表现出相反的辨别。在随后的实验阶段，除了短潜伏期（25毫秒）的深层板层原始辨别在整个反转训练中持续存在外，所有辨别效应都减弱了。AV核的活动与行为同步，从原始辨别逐渐过渡到相反辨别。行为反转后给予的引起觉醒的足部电击分别在深层和浅层板层诱发了原始辨别和相反辨别。这些数据被解释为表明扣带回皮质和丘脑前部在编码条件刺激的关联意义方面的作用。
