长春碱类似物与微管蛋白的相互作用。
Interaction of vinblastine analogues with tubulin.
作者信息
Zavala F, Guénard D, Potier P
出版信息
Experientia. 1978 Nov 15;34(11):1479-9. doi: 10.1007/BF01932374.
PMID:720478
Abstract
Studies of the interaction between vinblastine-like alkaloids and their receptor, i.e. tubulin, are reported. They shed some light on the structure-activity relationships in this medicinally important series: the configurations at C14' and C16' as well as the presence of the methoxycarbonyl group on C16' seem to play an essential role in the determination of biological activity.
摘要
报道了长春碱样生物碱与其受体即微管蛋白之间相互作用的研究。这些研究为这一具有重要药用价值的系列化合物的构效关系提供了一些线索：C14'和C16'位的构型以及C16'位甲氧基羰基的存在似乎在生物活性的决定中起着至关重要的作用。
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