小鼠实验性自身免疫性重症肌无力的遗传控制。II. 淋巴细胞对乙酰胆碱受体的增殖反应依赖于Lyt-1+23-细胞。
Genetic control of experimental autoimmune myasthenia gravis in mice. II. Lymphocyte proliferative response to acetylcholine receptor is dependent on Lyt-1+23- cells.
作者信息
Christadoss P, Krco C J, Lennon V A, David C S
出版信息
J Immunol. 1981 Apr;126(4):1646-7.
PMID:7204982
Abstract
The proliferative response of regional lymph node lymphocytes to Torpedo acetylcholine receptor (TAR) is under H-2 linked Ir gene control. In high responder B6 (H-2b) congenic mice, lymphocytes that proliferate in vitro in response to TAR are dependent on T cells of a subpopulation expressing the phenotype associated with helper functions, Lyt-1+23-.
摘要
局部淋巴结淋巴细胞对电鳐乙酰胆碱受体（TAR）的增殖反应受H-2连锁免疫反应基因（Ir基因）控制。在高反应性的B6（H-2b）同源基因小鼠中，体外对TAR产生增殖反应的淋巴细胞依赖于表达与辅助功能相关表型（Lyt-1+23-）的亚群T细胞。
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