Lenman J A, Fleming A M, Robertson M A, Abbott R J, Clee M D, Ferguson I F, Wright D S
J Neurol Neurosurg Psychiatry. 1981 Jan;44(1):54-61. doi: 10.1136/jnnp.44.1.54.
Clinical examination of 80 patients with bronchial carcinoma showed minor neurological abnormalities but in only a few cases were these considered to be due to neuromyopathy. Spontaneous activity in the EMG was shown in 35%, consistent with a mild degree of partial denervation; when 50 of the patients were matched with 50 controls the patients showed a small but significant impairment of nerve conduction velocity in comparison with the controls. These findings accord with subclinical neuropathy in a high proportion of patients with bronchial carcinoma consistent with primary axonal change. Thirty patients participated in a prospective study of the effects of treatment. Of these nine were reassessed following surgery or radiotherapy. Although there was a trend towards improvement in sensory conduction there was no consistent change in the electromyographic findings.
对80例支气管癌患者的临床检查显示，有轻微的神经功能异常，但只有少数病例被认为是由神经肌肉病变引起的。35%的患者肌电图显示有自发活动，这与轻度部分失神经支配相一致；当将50例患者与50例对照者进行匹配时，与对照组相比，患者的神经传导速度有轻微但显著的损害。这些发现表明，相当一部分支气管癌患者存在亚临床神经病变，与原发性轴索改变一致。30例患者参与了一项关于治疗效果的前瞻性研究。其中9例在手术或放疗后进行了重新评估。尽管感觉传导有改善的趋势，但肌电图检查结果并无一致变化。
