Fowler J S, MacGregor R R, Wolf A P, Farrell A A, Karlstrom K I, Ruth T J
J Nucl Med. 1981 Apr;22(4):376-80.
A remotely operated, shielded synthesis system for the production of 2-deoxy-2-[18F]fluoro-D-glucose (18FDG) for clinical studies has been developed. Using this system, 25 mCi of 18FDG are produced a the end of a 60-min synthesis from approximately 300 mCi of F-18 (total F-18 recovered from the target at the end of bombardment). The fractional distribution of F-18 among various components of the synthesis system has been measured. This yield of 18FDG (25 mCi) is ample for two consecutive human studies in house or for shipment to collaborating institutions within a 3-hr (door to door) radius.
已开发出一种用于临床研究的生产2-脱氧-2-[¹⁸F]氟-D-葡萄糖（¹⁸FDG）的远程操作屏蔽合成系统。使用该系统，在60分钟的合成结束时，由大约300毫居里的F-18（轰击结束时从靶中回收的总F-18）可生产出25毫居里的¹⁸FDG。已测量了F-18在合成系统各组分中的分布分数。该¹⁸FDG产量（25毫居里）足以满足机构内部连续两项人体研究的需求，或在3小时（门到门）半径范围内运往合作机构。
