Gurwitz D, Mindorff C, Levison H
J Pediatr. 1981 Apr;98(4):551-5. doi: 10.1016/s0022-3476(81)80758-5.
To assess bronchial reactivity in children who have had bronchiolitis, we studied 48 children by challenging them with methacholine nine or ten years after admission to hospital with bronchiolitis. Pulmonary function was also evaluated. Fifty-seven percent of children studied had bronchial hyperreactivity. Thirty-three percent of first-degree relatives of those with a positive MCH challenge had a positive response. There was a significant correlation between the occurrence of a positive MCH challenge and a history of recurrent bronchiolitis. Pulmonary function tests demonstrated lower flow rates in the positive responders. Fourteen children had a history of asthma or wheezing, but this did not appear to be severe or frequent, and few required long-term therapy. There appears to be a strong genetic component in the prevalence of bronchial reactivity in these children. Bronchial hyperreactivity may be a risk factor in the development of COPD.
为评估患过细支气管炎的儿童的支气管反应性，我们对48名儿童进行了研究，这些儿童在因细支气管炎住院九或十年后接受了乙酰甲胆碱激发试验。同时也评估了肺功能。接受研究的儿童中有57%存在支气管高反应性。乙酰甲胆碱激发试验阳性者的一级亲属中有33%呈阳性反应。乙酰甲胆碱激发试验阳性的发生与复发性细支气管炎病史之间存在显著相关性。肺功能测试显示阳性反应者的流速较低。14名儿童有哮喘或喘息病史，但似乎并不严重或频繁，很少需要长期治疗。在这些儿童中，支气管反应性的患病率似乎有很强的遗传因素。支气管高反应性可能是慢性阻塞性肺疾病（COPD）发展的一个危险因素。
