Simon J, Migeon J, Lecornu P
J Radiol. 1980 Dec;61(12):797-802.
Bone calcium content was studied in 200 children who had received long-term therapy with anticonvulsants or corticoids, or who presented retarded growth (more particularly, pituitary deficiency treated with somatotropin, thyroid deficiency treated with thyroid extracts, or Turner's syndrome). It was demonstrated that 25 p. cent of children on anticonvulsant therapy, 30 p. cent of those on corticoid treatment, and nearly all those with retarded growth had a mineral content much below normal levels. Bone densitometry by absorption of a monochromatic iodine-125 beam is a rapid, precise method, which is not dangerous at the dose delivered, and appears to be well adapted for surveillance of children with anomalies in calcium content.
对200名长期接受抗惊厥药或皮质类固醇治疗的儿童,或生长发育迟缓(尤其是接受生长激素治疗的垂体功能减退、接受甲状腺提取物治疗的甲状腺功能减退或特纳综合征)的儿童进行了骨钙含量研究。结果表明,接受抗惊厥药治疗的儿童中有25%,接受皮质类固醇治疗的儿童中有30%,几乎所有生长发育迟缓的儿童骨矿物质含量均远低于正常水平。通过吸收单色碘-125束进行骨密度测定是一种快速、精确的方法,在所用剂量下并无危险,似乎非常适合监测钙含量异常的儿童。