Matthew G
Farmakol Toksikol. 1978 Nov-Dec;41(6):701-4.
In 75 patients with circulatory insufficiency of various degree the diuretic effect of moduretic was studied. In 25 of them besides the potassium and sodium metabolism and in 33 others, with a background of chronic ischemic disease of the heart and hypertensive disease, the state of the hemocoagulation system was investigated in the moduretic medication. In 24 patients with hypertensive disease of the I--IIA stage subject to study was the effect of moduretic on the arterial pressure, with this drug administered by mouth in doses of 3 to 1/2 tablet a day. The drug proved to have a marked duretic effect in patients with different degree of circulatory insufficiency. It increases sodium excretion with urine and retains potassium in the organism, without causing hyperkaliemia. In patients with circulatory insufficiency of the I degree the drug can provoke thrombogenesis and in cases of the IIA, IIB and III degree may be considered a drug of choice. Moduretic brings down the systolic and diastolic pressure in patients with hypertensive disease of the I and II stages.
对75例不同程度循环功能不全的患者研究了速尿的利尿作用。其中25例除研究钾和钠代谢外，另外33例在慢性缺血性心脏病和高血压病背景下，在服用速尿期间研究了血液凝固系统的状态。对24例Ⅰ - ⅡA期高血压病患者，研究了速尿对动脉血压的影响，该药口服给药，剂量为每日3至半片。结果证明，该药对不同程度循环功能不全的患者有显著利尿作用。它可增加尿钠排泄并在体内保留钾，不会引起高钾血症。在Ⅰ度循环功能不全的患者中，该药可诱发血栓形成，而在ⅡA、ⅡB和Ⅲ度循环功能不全的情况下，可被视为首选药物。速尿可降低Ⅰ期和Ⅱ期高血压病患者的收缩压和舒张压。
