Tetrahydro-2-benzoxepins: a novel family of hypotensives.

TenBrink R E, McCall J M, Pals D T, McCall R B, Orley J, Humphrey S J, Wendling M G

J Med Chem. 1981 Jan;24(1):64-7. doi: 10.1021/jm00133a014.

A novel series of 1-(alkylamino)-1,3,4,5-tetrahydro-7,8-dimethoxy-2-benzoxepins shows hypotensive activity. A typical example is 1-[2-(1,3,4,5-tetrahydro-7,8-dimethoxy-2-benzoxepin-1-yl)ethyl]-4-(4-fluorophenyl)piperazine. This compound is an alpha blocker with peripheral and central activities.