TenBrink R E, McCall J M, Pals D T, McCall R B, Orley J, Humphrey S J, Wendling M G
J Med Chem. 1981 Jan;24(1):64-7. doi: 10.1021/jm00133a014.
A novel series of 1-(alkylamino)-1,3,4,5-tetrahydro-7,8-dimethoxy-2-benzoxepins shows hypotensive activity. A typical example is 1-[2-(1,3,4,5-tetrahydro-7,8-dimethoxy-2-benzoxepin-1-yl)ethyl]-4-(4-fluorophenyl)piperazine. This compound is an alpha blocker with peripheral and central activities.
一系列新型的1-（烷基氨基）-1,3,4,5-四氢-7,8-二甲氧基-2-苯并氧杂卓显示出降压活性。一个典型的例子是1-[2-（1,3,4,5-四氢-7,8-二甲氧基-2-苯并氧杂卓-1-基）乙基]-4-（4-氟苯基）哌嗪。该化合物是一种具有外周和中枢活性的α受体阻滞剂。
