Kikumoto R, Tobe A, Tonomura S
J Med Chem. 1981 Feb;24(2):145-8. doi: 10.1021/jm00134a004.
A series of substituted (omega-aminoalkoxy)benzene derivatives has been synthesized and screened for potential antidepressant activities. The effect of structural variation of these molecules has been systematically examined. Antidepressant activity was clearly displayed by 2-benzyl-1-[4-(methylamino)butoxy]benzene (7), 2-(2-hydroxybenzyl)-1-[4-(methylamino)butoxy]benzene (19), 1-[4-(methylamino)butoxy]-2-phenoxybenzene (29), and 1-[4-(methylamino)butoxy]-2-(phenylthio)benzene (31) in further pharmacological studies. These compounds did not possess the anticholinergic, antihistaminic, and muscle-relaxant side effects common to tricyclic antidepressants.
已经合成了一系列取代的（ω-氨基烷氧基）苯衍生物，并对其潜在的抗抑郁活性进行了筛选。系统地研究了这些分子结构变化的影响。在进一步的药理研究中，2-苄基-1-[4-（甲氨基）丁氧基]苯（7）、2-（2-羟基苄基）-1-[4-（甲氨基）丁氧基]苯（19）、1-[4-（甲氨基）丁氧基]-2-苯氧基苯（29）和1-[4-（甲氨基）丁氧基]-2-（苯硫基）苯（31）显示出明显的抗抑郁活性。这些化合物不具有三环类抗抑郁药常见的抗胆碱能、抗组胺和肌肉松弛副作用。
