Miró-Quesada M, Crosby E, Gotuzzo E, Guerra J, Carrillo C
Johns Hopkins Med J. 1981 Feb;148(2):73-7.
Abnormalities of hemostasis in vivo and in vitro were defined in a prospective study of patients with typhoid fever. In a group of 56 patients with a proven diagnosis of typhoid fever, hemostatic abnormalities were frequently found. In patients with normal clotting tests the fibrinogen level was found to be higher than in normal controls. This finding established a new normal level for patients with typhoid fever. Using this redefined normal level it was found that low fibrinogen was associated with other hemostatic abnormalities. Low fibrinogen levels in patients with typhoid fever are possibly the result of disseminated intravascular coagulation. This process affected 20% of our patients and was often of mild to moderate intensity. Clinically significant bleeding occurred in 18 patients and, in contrast to the results of previously published studies, was found to correlate with clotting abnormalities.
在一项针对伤寒热患者的前瞻性研究中，对体内和体外止血异常进行了定义。在一组确诊为伤寒热的56例患者中，经常发现止血异常。在凝血试验正常的患者中，发现纤维蛋白原水平高于正常对照组。这一发现确立了伤寒热患者的新正常水平。使用这个重新定义的正常水平发现，低纤维蛋白原与其他止血异常有关。伤寒热患者的低纤维蛋白原水平可能是弥散性血管内凝血的结果。这个过程影响了我们20%的患者，且通常为轻度至中度。18例患者发生了具有临床意义的出血，与先前发表的研究结果相反，发现其与凝血异常相关。
