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[海马神经元和神经胶质细胞中条件性食物反射的形成与蛋白质周转]

[Elaboration of a conditioned alimentary reflex and protein turnover in hippocampal neurons and neuroglia].

作者信息

Glushchenko T S, Kulagin D A, Lopatina N G, Pevzner L Z

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1978 Oct;64(10):1386-90.

PMID:720667
Abstract

A single session of the food conditioning in rats entailed an increase of labelled phenylalanine incorporation into the proteins of the nuclei and, particularly, of the cytoplasm of CA3 hippocampal neurons. In the trained animals, as compared with active control group, a session repeated in 3 days returned the turnover of neuronal proteins to the control level, while the same session in 6 days of decreased the protein turnover below the control level. No changes occurred in the course of the experiment in the perineuronal neuroglial cells. Predominant involvement of neuronal protein metabolism is outlined in the metabolic reconstruction within the whole neuron-neuroglia unit in the course of conditioning.

摘要

大鼠单次食物条件反射会使标记的苯丙氨酸掺入海马CA3区神经元细胞核尤其是细胞质蛋白质的量增加。与主动对照组相比,训练后的动物若3天重复一次该条件反射,神经元蛋白质周转会恢复到对照水平,而若6天重复一次相同条件反射,则蛋白质周转低于对照水平。实验过程中神经周神经胶质细胞无变化。在条件反射过程中,整个神经元-神经胶质单元的代谢重建突显了神经元蛋白质代谢的主要参与情况。

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