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[正常条件下及异烟肼处理后大鼠海马神经元在食物性条件反射形成过程中蛋白质水平的变化]

[Changes in the protein level in rat hippocampal neurons during development of the alimentary conditioned reflex under normal conditions and after treatment with iproniazid].

作者信息

Segal O L, Mats V N, Kruglikov R I

出版信息

Nauchnye Doki Vyss Shkoly Biol Nauki. 1987(4):55-60.

PMID:3593805
Abstract

The protein content in neurons of areas CA-1 and CA-3 of the dorsal hippocampus has been determined by means of cytointerferometry in rats during elaboration of unlocal alimentary instrumental reflex (ULAIR) and local alimentary instrumental reflex (LAIR) on the background of increased and normal serotonine content in the brain. It has been found that during the ULAIR elaboration the hippocampal neurons react by an increase of dry mass, during the LAIR elaboration-by its decrease. Under condition of serotonine excess in the brain the changes of dry mass in hippocampal neurons during elaboration of the two reflexes are opposite to these observed during the ULAIR and LAIR elaboration with normal serotonine content.

摘要

在大脑血清素含量增加和正常的背景下,通过细胞干涉测量法测定了大鼠在建立非局部食物性工具性反射(ULAIR)和局部食物性工具性反射(LAIR)过程中背侧海马CA-1和CA-3区神经元中的蛋白质含量。结果发现,在建立ULAIR过程中,海马神经元的干重增加,而在建立LAIR过程中,干重减少。在大脑血清素过量的情况下,建立这两种反射时海马神经元干重的变化与血清素含量正常时建立ULAIR和LAIR过程中观察到的变化相反。

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