Horrobin D F, Trosko J E
Med Hypotheses. 1981 Jan;7(1):115-25. doi: 10.1016/0306-9877(81)90027-x.
Diazepam has the characteristics of a tumour promoter in a number of in vitro systems. The effect is apparent at concentrations of diazepam which are clinically relevant. Diazepam also accelerated tumour growth in two different experimental animal cancers. Tranquillizer use was found to be greater in women with metastatic breast cancer at the time of diagnosis than in those without metastases. Further evaluation of the possible effects of diazepam and related drugs on human and animal cancers is urgently required.
在许多体外系统中，地西泮具有肿瘤促进剂的特性。在与临床相关的地西泮浓度下，这种作用很明显。地西泮还加速了两种不同实验动物癌症的肿瘤生长。研究发现，转移性乳腺癌女性在诊断时使用镇静剂的频率高于无转移的女性。迫切需要进一步评估地西泮及相关药物对人类和动物癌症可能产生的影响。
