Stewart P A, Percy M E, Chang L S, Thompson M W
Muscle Nerve. 1981 Mar-Apr;4(2):165-73. doi: 10.1002/mus.880040214.
In both normal chicks and chicks with hereditary muscular dystrophy the BB (brain) and MB (hybrid) isozymes were the predominant forms of creatine kinase (CK) activity in embryonic skeletal muscle. As myogenesis progressed, activity due to the MM (muscle) isozyme progressively increased, and by 1 week ex ovo, the MM isozyme accounted for approximately 97% of total muscle activity in both genotypes. During this time, the proportion of the MM isozyme was slightly but significantly lower in dystrophic muscles. After hatching the proportion of the MB isozyme and its total activity decreased in normal muscle, but increased in dystrophic pectoral muscle, and by 5 months ex ovo, the MB isozyme accounted for 10% of total CK activity. Prior to hatching there was no consistent difference in total CK activity between normal and dystrophic tissues, but by 1 week after hatching and thereafter, total CK activity was significantly lower in dystrophic pectoral muscle.
在正常雏鸡和患有遗传性肌肉萎缩症的雏鸡中，BB（脑型）和MB（杂交型）同工酶是胚胎骨骼肌中肌酸激酶（CK）活性的主要形式。随着肌生成的进展，MM（肌肉型）同工酶的活性逐渐增加，到出壳后1周时，MM同工酶在两种基因型的肌肉总活性中约占97%。在此期间，营养不良肌肉中MM同工酶的比例略低但显著降低。孵化后，正常肌肉中MB同工酶的比例及其总活性下降，但在营养不良的胸肌中增加，到出壳后5个月时，MB同工酶占CK总活性的10%。孵化前，正常组织和营养不良组织之间的总CK活性没有一致的差异，但在孵化后1周及之后，营养不良胸肌中的总CK活性显著降低。
