Hondeghem L M, Lam C
Naunyn Schmiedebergs Arch Pharmacol. 1980 Aug;313(1):11-6. doi: 10.1007/BF00505798.
Concentrations of lidocaine which minimally decrease conduction and excitability of normal canine Purkinje fibers markedly decrease these parameters in fibers depolarized by metabolic depression (DNP superfusion). The decrease in Vmax and the slowing of the post-stimulation recovery of Vmax by lidocaine are also more marked during DNP superfusion than during superfusion with a DNP-free salt solution. Since these effects could be reversed by a lidocaine-free DNP superfusion, it is concluded that lidocaine selectivity depresses the electrical activity of tissue depolarized by the metabolic inhibitor DNP. This selective depressive action of lidocaine is similar to that observed in cardiac tissues depolarized by other means.
利多卡因浓度在正常犬浦肯野纤维中使传导和兴奋性降至最低时，在因代谢抑制（二硝基酚灌注）而发生去极化的纤维中会显著降低这些参数。与用不含二硝基酚的盐溶液灌注相比，在二硝基酚灌注期间，利多卡因使最大上升速率（Vmax）降低以及刺激后Vmax恢复减慢的作用也更明显。由于这些效应可通过无利多卡因的二硝基酚灌注逆转，因此得出结论，利多卡因选择性抑制被代谢抑制剂二硝基酚去极化的组织的电活动。利多卡因的这种选择性抑制作用类似于在通过其他方式去极化的心脏组织中观察到的情况。
