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Reductive and oxidative metabolism of nitrofurantoin in rat liver.

作者信息

Jonen H G

出版信息

Naunyn Schmiedebergs Arch Pharmacol. 1980;315(2):167-75. doi: 10.1007/BF00499260.

DOI:10.1007/BF00499260
PMID:7207645
Abstract
摘要

相似文献

1
Reductive and oxidative metabolism of nitrofurantoin in rat liver.呋喃妥因在大鼠肝脏中的还原代谢和氧化代谢。
Naunyn Schmiedebergs Arch Pharmacol. 1980;315(2):167-75. doi: 10.1007/BF00499260.
2
Microsomal oxidative stress induced by NADPH is inhibited by nitrofurantoin redox biotranformation.NADPH 诱导的微粒体氧化应激被呋喃妥因的氧化还原生物转化所抑制。
Free Radic Res. 2014 Feb;48(2):129-36. doi: 10.3109/10715762.2013.836695. Epub 2013 Oct 18.
3
Reductive metabolism of nitrofurantoin in the rat.呋喃妥因在大鼠体内的还原代谢。
Drug Metab Dispos. 1978 Jul-Aug;6(4):403-11.
4
Reduction of nitroheterocyclic drugs by ascorbate and catecholamines: a possible mechanism for the neurotoxicity of nitroheterocyclic drugs.
Basic Life Sci. 1988;49:787-94. doi: 10.1007/978-1-4684-5568-7_126.
5
Reductive metabolism of nitrofurantoin by rat lung and liver in vitro.大鼠肺和肝脏在体外对呋喃妥因的还原代谢
Biochem Pharmacol. 1986 Feb 15;35(4):575-80. doi: 10.1016/0006-2952(86)90350-3.
6
In vitro metabolism of [14C]rubratoxin B by rat hepatic subcellular fractions.大鼠肝脏亚细胞组分对[14C]红曲霉素B的体外代谢
Food Cosmet Toxicol. 1979 Apr;17(2):111-6. doi: 10.1016/0015-6264(79)90207-4.
7
Liver microsomal biotransformation of nitro-aryl drugs: mechanism for potential oxidative stress induction.硝基芳基药物的肝脏微粒体生物转化：潜在氧化应激诱导机制
J Appl Toxicol. 2004 Nov-Dec;24(6):519-25. doi: 10.1002/jat.999.
8
Metabolic activation of oxygen by nitrofurantoin in the young chick.呋喃妥因在幼雏体内对氧的代谢激活作用。
Toxicol Appl Pharmacol. 1982 Aug;65(1):162-9. doi: 10.1016/0041-008x(82)90374-x.
9
Alterations in cellular intermediary metabolism by 4-dimethylaminophenol in the isolated perfused rat liver and the implications for 4-dimethylaminophenol toxicity.
Biochem Pharmacol. 1980 Jun 15;29(12):1747-53. doi: 10.1016/0006-2952(80)90135-5.
10
Oxidative bioactivation of nitrofurantoin in rat liver microsomes.呋喃妥因在大鼠肝微粒体中的氧化生物活化作用。
Xenobiotica. 2017 Feb;47(2):103-111. doi: 10.3109/00498254.2016.1164913. Epub 2016 Apr 19.

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Oxidation and Reduction of Hydrazones-Risk Factors Related to the Manufacture and Stability of the Drugs.腙的氧化与还原——与药物制造和稳定性相关的风险因素
Int J Mol Sci. 2025 May 1;26(9):4295. doi: 10.3390/ijms26094295.
2
Effect of pregnancy on nitrofurantoin disposition in mice.妊娠对小鼠体内呋喃妥因处置的影响。
J Pharm Sci. 2009 Nov;98(11):4306-15. doi: 10.1002/jps.21698.
3
Nitrofurantoin-induced cholestatic hepatitis from cow's milk in a teenaged boy.一名青少年男性因饮用牛奶引发呋喃妥因所致胆汁淤积性肝炎

本文引用的文献

1
Studies on the induction of CO-binding pigments in liver microsomes by phenobarbital and 3-methylcholanthrene.苯巴比妥和3-甲基胆蒽对肝微粒体中一氧化碳结合色素诱导作用的研究。
Biochem Biophys Res Commun. 1967 Nov 30;29(4):521-6. doi: 10.1016/0006-291x(67)90515-3.
2
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
3
Renal excretion of nitrofurantoin (furadantin).呋喃妥因（呋喃旦啶）的肾脏排泄
West J Med. 1984 Feb;140(2):278-80.
Am J Physiol. 1959 Sep;197:580-4. doi: 10.1152/ajplegacy.1959.197.3.580.
4
Metabolic degradation of the nitrofurans.硝基呋喃的代谢降解
J Med Pharm Chem. 1960 Oct;2:563-84. doi: 10.1021/jm50012a007.
5
Studies on the absorption, distribution and elimination of nitrofurantoin in the rat.
J Pharmacol Exp Ther. 1961 Jan;131:38-43.
6
The reaction of nitrofurans with bacteria. III. Reduction of a series of antibacterial nitrofurans (type B compounds) by Aerobacter aerogenes.
J Med Pharm Chem. 1959 Apr;1(2):155-64. doi: 10.1021/jm50003a003.
7
The enzymatic reduction of chloramphenicol, p-nitrobenzoic acid and other aromatic nitro compounds in mammals.哺乳动物中氯霉素、对硝基苯甲酸及其他芳香族硝基化合物的酶促还原作用。
J Pharmacol Exp Ther. 1957 Feb;119(2):197-207.
8
Enhanced biotransformation of nitrofurantoin in rats after induction with 3-methylcholanthrene or beta-naphthoflavone.用3-甲基胆蒽或β-萘黄酮诱导后大鼠体内呋喃妥因的生物转化增强。
Biochem Pharmacol. 1980 Feb;29(2):263-6. doi: 10.1016/0006-2952(80)90340-8.
9
Nitrofurantoin-induced chronic active hepatitis.
Ann Intern Med. 1980 Jan;92(1):62-4. doi: 10.7326/0003-4819-92-1-62.
10
Chronic active hepatitis and severe hepatic necrosis associated with nitrofurantoin.慢性活动性肝炎及与呋喃妥因相关的严重肝坏死。
Ann Intern Med. 1980 Jan;92(1):14-9. doi: 10.7326/0003-4819-92-1-14.