Olanow C W, Finn A L
Neurosurgery. 1981 Jan;8(1):112-7. doi: 10.1227/00006123-198101000-00022.
Phenytoin is a highly effective anticonvulsant medication that is considered to be the treatment of choice for generalized major motor and focal epileptic seizures. An understanding of the pharmacokinetic properties of phenytoin greatly facilitates the management of seizure patients. The judicious use of serum-monitoring techniques coupled with careful clinical evaluations enable one to obtain the optimal anticonvulsant effect, freedom from dose-related toxicity, and the avoidance of unnecessary polypharmacy.
苯妥英是一种高效的抗惊厥药物，被认为是全身性大发作和局灶性癫痫发作的首选治疗药物。了解苯妥英的药代动力学特性极大地有助于癫痫患者的管理。明智地使用血清监测技术并结合仔细的临床评估，能够使患者获得最佳的抗惊厥效果、避免剂量相关毒性，并避免不必要的联合用药。
