Ylikoski J, Morra B, Hernandez I
ORL J Otorhinolaryngol Relat Spec. 1981;43(1):17-25. doi: 10.1159/000275521.
The superior vestibular nerve was studied histologically in 25 patients who underwent removal of inferior vestibular nerve schwannoma. In most cases, the nerve fibers were structurally normal but the endoneurial space showed various degrees of capillary stasis and/or extravasation of red blood cells. Increased fibrosis of the endoneurial space was seen in about two-thirds of the cases; it was mild in all except two cases. The endoneurial space appeared edematic in about one-third of the cases. Wallerian degeneration of individual fibers was occasionally observed in most cases and was severe in the two cases with moderate or severe endoneurial fibrosis. In about one-third of the cases there were large numbers of myelinated nerve fibers with thinned myelin sheaths. The observed structural changes are compatible with those seen in human and experimentally induced chronic compressive or entrapment neuropathies. Thus, early symptoms of eighth-nerve tumors might develop due to direct compression of the eighth-nerve trunk within the internal auditory canal.
对25例接受前庭下神经鞘瘤切除术的患者的前庭上神经进行了组织学研究。在大多数情况下，神经纤维结构正常，但神经内膜间隙显示出不同程度的毛细血管淤滞和/或红细胞外渗。约三分之二的病例可见神经内膜间隙纤维化增加；除两例外，其余均为轻度。约三分之一的病例中神经内膜间隙出现水肿。在大多数病例中偶尔观察到个别纤维的瓦勒变性，在两例中度或重度神经内膜纤维化的病例中较为严重。约三分之一的病例中有大量髓鞘变薄的有髓神经纤维。观察到的结构变化与人类和实验性诱导的慢性压迫性或卡压性神经病变中所见的变化一致。因此，第八脑神经肿瘤的早期症状可能是由于内耳道内第八脑神经干受到直接压迫所致。
