Dulery B, Hammami M, Chessebeuf M, Legendre M, Noly P, Padieu P, Maume B F
Nouv Presse Med. 1980 Dec 22;9(49):3729-32.
In vitro and in vivo studies using capillary column gas chromatography alone or coupled with mass spectrometry resulted in the identification of several metabolites of fenofibrate (LF 178). Fenofibric acid (LF 153) was omnipresent, being found in rats after acute, subacute and chronic administration, in human urine during chronic treatment, and in cultures of rat and human liver cells. Other metabolites were LF 433 (LF 153 benzhydrol), which increases in rats with the duration of treatment while LF 153 decreases, and LF - phenol" found in human urine. In hepatocyte cultures, fenofibric acid was predominant, but fenofibrate itself and LF 321 (LF 178 benzhydrol) were also present in addition to the above-mentioned metabolites. LF 321, however, was only found in human liver cell cultures.
单独使用毛细管柱气相色谱法或与质谱联用进行的体外和体内研究，鉴定出了非诺贝特（LF 178）的几种代谢物。非诺贝酸（LF 153）普遍存在，在大鼠急性、亚急性和慢性给药后均可发现，在慢性治疗期间的人类尿液中以及大鼠和人类肝细胞培养物中也能找到。其他代谢物包括LF 433（LF 153二苯甲醇），其在大鼠体内随治疗时间延长而增加，而LF 153则减少，以及在人类尿液中发现的“LF - 苯酚”。在肝细胞培养物中，非诺贝酸占主导地位，但除上述代谢物外，非诺贝特本身和LF 321（LF 178二苯甲醇）也存在。然而，LF 321仅在人类肝细胞培养物中发现。
