Martens V, Bentsen P, Hochrein H
Pharmatherapeutica. 1980;2(7):456-61.
Eight patients with essential hypertension each received a single oral dose of 1 capsule of a sustained-release formulation of 0.25 mg clonidine in the morning for 3 consecutive days. Pulse ratio and blood pressure were measured in the standing and supine positions at specific intervals. After the first day of treatment, a significant decrease in blood pressure lasting 24 hours was recorded for the standing position. In the supine position, there was a progressive decrease in blood pressure which also attained significance on the third day of treatment. There was a progressive and significant reduction in mean arterial pressure from the first to the third day.
8名原发性高血压患者，每人连续3天每天早晨口服1粒0.25毫克可乐定缓释制剂胶囊。在特定时间间隔测量站立位和仰卧位的脉率和血压。治疗第一天后，站立位记录到血压显著下降且持续24小时。仰卧位血压呈进行性下降，在治疗第三天也达到显著水平。从第一天到第三天，平均动脉压呈进行性且显著降低。
