Hillelson R L, Glowacki J, Healey N A, Mulliken J B
Plast Reconstr Surg. 1980 Oct;66(4):528-33. doi: 10.1097/00006534-198010000-00004.
Rat dorsal skin flaps predictably underwent full-thickness necrosis by 48 hours when hematoma had been placed beneath the flap. Microangiographic studies demonstrated failure of filling of the distal vasculature of these flaps. This was in marked contrast to the complete reestablishment of circulation in control flaps, overlying equal volumes of serum. The circulation of failing flaps overlying hematoma was restored with isoxsuprine given parenterally 1 hour preoperatively and every 4 hours for 24 hours postoperatively. This pharmacologic regimen gave consistent reestablishment of flap perfusion and flap survival. The toxic component of hematoma acts on the circulation to a skin flap. This may be at the same level of the vasculature as the vasodilating action of isoxsuprine.
当在大鼠背部皮瓣下放置血肿时，皮瓣在48小时内可预测地发生全层坏死。微血管造影研究显示这些皮瓣的远端血管系统未能充盈。这与覆盖等量血清的对照皮瓣循环完全重建形成鲜明对比。术前1小时和术后24小时每4小时胃肠外给予异克舒令，可恢复覆盖血肿的失败皮瓣的循环。这种药物治疗方案使皮瓣灌注和皮瓣存活得到持续重建。血肿的毒性成分作用于皮瓣的循环。这可能与异克舒令的血管舒张作用处于血管系统的同一水平。
