[Edematous changes in the ultrastructure of the neocortex of Wistar rats following the application of angiotensin II].

In 80 Wistar rats were investigated the prolonged action of Angiotensin II in a dosage of 0,05 mg/kg/die ip. appl. on microstructures of the sensomotoric cortex. It is observed, after the first application, a biphasic reaction of brain vessels, in the beginning a pronounced vasodilatation (5 min p.-inject) which 10 min later turn into a vasoconstriction. In correlation with the applications frequency the repeated injection of the octapeptide leads to perivascular edemas. Neurons of the sensomotoric cortex show strong swellings, which later turn in to involutions. Pronounced destructions of mitochondria are demonstrable. Conceivable mechanisms were discussed.