乙醇诱导的大鼠小肠损伤。乙醇对肠道碱性磷酸酶粪便排泄的影响。

Damage of rat small intestine induced by ethanol. Effect of ethanol on fecal excretion of intestinal alkaline phosphatase.

作者信息

Hufnagel H, Bode C, Bode J C, Lehmann F G

出版信息

Res Exp Med (Berl). 1980;178(1):65-70. doi: 10.1007/BF01856759.

PMID:7209135

Abstract

Single administration of ethanol or alcoholic beverages (5g ethanol/kg body weight) induces a decrease of the 24h excretion of fecal intestinal alkaline phosphatase (I-AP) activity of 28% (P less than 0.05) in comparison to controls (0.9% saline). Administration of higher amounts of 20% (v/v) ethanol (8g/kg body weight on 3 consecutive days) yields a decrease of fecal I-AP excretion up to 82% (P less than 0.005) in comparison to controls (saturated glucose solution). The interpretation of these results as a toxic effect of ethanol to small intestinal mucosa was supported by measurement of enzymatic activity in the small intestinal mucosa and by morphometric data.

摘要

单次给予乙醇或酒精饮料（5克乙醇/千克体重），与对照组（0.9%生理盐水）相比，会导致粪便肠碱性磷酸酶（I-AP）活性24小时排泄量降低28%（P<0.05）。连续三天给予更高剂量的20%（v/v）乙醇（8克/千克体重），与对照组（饱和葡萄糖溶液）相比，粪便I-AP排泄量降低高达82%（P<0.005）。小肠黏膜中酶活性的测量以及形态计量学数据支持了将这些结果解释为乙醇对小肠黏膜的毒性作用。