Bille-Brahe N E, Engell H C, Sørensen M B
Surg Gynecol Obstet. 1981 Feb;152(2):183-6.
This study was undertaken to investigate the hemodynamic effect of prophylactic digitalization before major surgical procedures. Sixteen patients, all admitted for an elective vascular operation for arteriosclerotic disease and all with impaired left ventricular function, were investigated. In half of the patients, digitalis was given before the operation, the other half of the patients served as the control study. The measured parameters were pulmonary artery mean pressure, pulmonary capillary wedge pressure, central venous pressure, mean arterial blood pressure, heart rate, cardiac output, blood volume and arterial, as well as venous, oxygen content. Preoperatively, before digitalization, no significant differences were noted between the two groups at rest and during exercise. Before anesthesia and postoperatively, those given digitalis had improved cardiac function. Those in both groups, however, had a normal hemodynamic response to the surgical trauma. In this study, a definite answer is not provided concerning the usefulness of prophylactic digitalization but an increase in the ability of the digitalized heart to withstand the imposition of a pressure load postoperatively is suggested.
本研究旨在探讨大手术前预防性洋地黄化的血流动力学效应。对16例因动脉硬化性疾病需择期进行血管手术且左心室功能受损的患者进行了研究。其中一半患者在手术前给予洋地黄，另一半患者作为对照研究。测量的参数包括肺动脉平均压、肺毛细血管楔压、中心静脉压、平均动脉血压、心率、心输出量、血容量以及动脉和静脉血氧含量。术前，在洋地黄化之前，两组患者在静息和运动时均未发现显著差异。麻醉前和术后，使用洋地黄的患者心功能有所改善。然而，两组患者对手术创伤均有正常的血流动力学反应。本研究未就预防性洋地黄化的有效性给出明确答案，但提示洋地黄化的心脏术后承受压力负荷的能力有所增强。
