Hilton J G
Surg Gynecol Obstet. 1981 Apr;152(4):441-7.
Plasma volume loss, cardiac output and hematocrit values have been measured in anesthetized dogs receiving a 15 per cent total body surface area third degree flame burn before and two, four and six hours postburn. One group of dogs received no fluid resuscitation. Five groups of dogs received fluid resuscitation with varying percentages of albumin added to the Ringer's lactate solution. Results of this study show that total fluid loss from the vascular bed increased as the result of fluid resuscitation. The amount of increase in total fluid loss was dependent upon the percentage of albumin in the resuscitation fluid. The higher the percentage of albumin, the lower the amount of total fluid loss. Following fluid resuscitation, cardiac output improved and the hematocrit level decreased toward normal. The amount of change of these variables was also related to the percentage of albumin in the resuscitation fluid. The greatest improvement in these variables was observed in that group of dogs receiving the greatest percentage of albumin in the resuscitation fluid. These results demonstrate that the administration of resuscitation fluid improves cardiovascular function following thermal injury and that the amount of improvement is related to the percentage of albumin present in fluid used for resuscitation.
在全身表面积15%的三度火焰烧伤的麻醉犬身上，于烧伤前以及烧伤后两小时、四小时和六小时测量了血浆容量损失、心输出量和血细胞比容值。一组犬未进行液体复苏。五组犬用添加了不同百分比白蛋白的乳酸林格氏液进行液体复苏。本研究结果表明，由于液体复苏，血管床的总液体损失增加。总液体损失的增加量取决于复苏液中白蛋白的百分比。白蛋白百分比越高，总液体损失量越低。液体复苏后，心输出量改善，血细胞比容水平降至正常。这些变量的变化量也与复苏液中白蛋白的百分比有关。在复苏液中白蛋白百分比最高的那组犬中，观察到这些变量有最大程度的改善。这些结果表明，给予复苏液可改善热损伤后的心血管功能，且改善程度与用于复苏的液体中白蛋白的百分比有关。
