Pakhomova V A, Skliar V E, Kriukova V E, Kozlianina N P, Skiba V Ia
Ukr Biokhim Zh (1978). 1981 Jan-Feb;53(1):30-4.
The activity of hexokinase, glucose-6-phosphate dehydrogenase, pyruvate dehydrogenase, isocytrate dehydrogenase, alpha-ketoglutarate dehydrogenase and the ATR content in the alveolar process and gingiva of dogs are established to decrease considerably in experimental cholestasis, induced by ligation of the common bile duct. Incorporation of tissue proteins into the Krebs cycle through the reverse NAD-dependent malate dehydrogenase reaction is a compensatory reaction favouring an increase of the ATP amount in the alveolar process.
实验性胆汁淤积是通过结扎胆总管诱导产生的,结果发现,犬牙槽突和牙龈中的己糖激酶、葡萄糖-6-磷酸脱氢酶、丙酮酸脱氢酶、异柠檬酸脱氢酶、α-酮戊二酸脱氢酶的活性以及ATR含量均显著降低。通过逆向NAD依赖的苹果酸脱氢酶反应将组织蛋白纳入三羧酸循环是一种代偿反应,有利于增加牙槽突中的ATP量。