Petutschnigk D, Herrmann M, Hirlinger W K
Z Mikrosk Anat Forsch. 1980;94(5):908-12.
About 500 ml of blood of young pigs weighing 20...25 mg were replaced by artificial blood substitute "Fluosol-DA 20%". Eight days after exchange the animals were sacrificed and the liver was fixed for electron microscopic investigation. The morphological studies showed Fluosol-droplets in the cytoplasma of parenchymal cells near the bile canaliculi and in the sinusoidal lining cells. Most Fluosol-droplets were found in the endothelial and Kupffer cells which both seemed to be completely filled. The ballooning of these cells often resulted in a partial occlusion of the sinusoids. The sinusoidal lining cells were saturated by Fluosol droplets to such an extent that they seemed to be unable to phagocytize further.
