Friedmann N, Thomas J, Carr R, Elders J, Ringdahl I, Roche A
Am J Dis Child. 1981 Apr;135(4):329-32. doi: 10.1001/archpedi.1981.02130280019007.
The growth of 22 children with attention deficit disorder (ADD) was monitored longitudinally for up to four years. Each child received at least one year of continuous, successful pemoline (Cylert) therapy, after which drug "vacations" were allowed. The effective dosage of pemoline ranged from 56 to 150 mg/day during the first year of treatment. Stature and weight measurements at six-month intervals were matched to those of paired "normal" children from the Fels Longitudinal Study. Significant deficits were observed for mean weight change at six and 12 months after baseline, and for mean stature change at 12 and 18 months after baseline. However, all subsequent six-month results up to four years did not differ significantly between the two groups. These results show a temporary retardation in the rate of growth in weight and stature with later catch-up growth in children treated wih pemoline.
对22名患有注意力缺陷障碍（ADD）的儿童进行了长达四年的纵向生长监测。每个孩子都接受了至少一年的持续、成功的匹莫林（赛乐特）治疗，之后允许停药“休假”。治疗第一年匹莫林的有效剂量范围为56至150毫克/天。每隔六个月测量一次身高和体重，并与来自费尔斯纵向研究的配对“正常”儿童的测量结果进行对比。在基线后6个月和12个月时观察到平均体重变化存在显著缺陷，在基线后12个月和18个月时观察到平均身高变化存在显著缺陷。然而，在长达四年的后续所有六个月的结果中，两组之间没有显著差异。这些结果表明，接受匹莫林治疗的儿童体重和身高增长速度暂时迟缓，但随后会出现追赶生长。
