Lee K P, Barras C E, Griffith F D, Waritz R S
Am J Pathol. 1981 Mar;102(3):314-23.
Rats, hamsters, and guinea pigs were exposed by inhalation to different concentrations of potassium octatitanate fibers. Following 3 months of exposure, the animals were sacrificed between the 15th and 24th month. The exposed animals showed dose-related dust deposition and pulmonary fibrosis mainly in the respiratory bronchiolar region. Most short fibers (less than 5 micrograms) were phagocytized by alveolar macrophages, but long fibers (greater than 10 micrograms) were phagocytized by foreign body giant cells. Dust-laden macrophages (dust cells) entered into the lumen of bronchial lymphatic or pulmonary blood vessels. Numerous dust cells were transported from the lung to the tracheobronchial and mediastinal lymph nodes where some dust cells penetrated into the blood or lymphatic circulation. Massive direct cell migration of the mediastinal adipose tissue from the lymph nodes occurred occasionally. Dust-laden giant cells were found only occasionally in the liver, and there was widespread migration of the fibers into other vital organs and tissues without any significant responses.
将大鼠、仓鼠和豚鼠通过吸入暴露于不同浓度的钛酸八钾纤维中。暴露3个月后，在第15至24个月之间处死动物。暴露的动物表现出与剂量相关的粉尘沉积和肺纤维化，主要发生在呼吸性细支气管区域。大多数短纤维（小于5微克）被肺泡巨噬细胞吞噬，但长纤维（大于10微克）被异物巨细胞吞噬。载尘巨噬细胞（尘细胞）进入支气管淋巴管或肺血管腔。大量尘细胞从肺转运至气管支气管和纵隔淋巴结，其中一些尘细胞进入血液或淋巴循环。偶尔会发生纵隔脂肪组织从淋巴结的大量直接细胞迁移。仅偶尔在肝脏中发现载尘巨细胞，并且纤维广泛迁移到其他重要器官和组织中，未产生任何明显反应。
