Demoulin A, Verstraelen-Proyard J, Bourguignon J P, Hustin J, Koulischer L, Bologne R, Franchimont P
Ann Endocrinol (Paris). 1980 Jul-Aug;41(4):291-302.
Mice testis in organ culture (31 degrees C) produce a steroid free substance which inhibits FSH secretion by rat pituitary cells. Histologically, Sterloti cells alone remain normal after a few days in culture. A hypothalamic action of inhibin is demonstrated in vitro. The intraglandular content in LHRH is inversely related to the amount of inhibin present in the culture medium. In the testis, DNA synthesis is depended of inhibin. This is demonstrated by studies of the incorporation of tritiated thymidine in testicular DNA in vivo and in vitro. In conclusion, inhibin is produced by Sertoli cells and acts not only at this pituitary level but also on the hypothalamus and the testis.
在器官培养（31摄氏度）条件下，小鼠睾丸产生一种无类固醇的物质，该物质可抑制大鼠垂体细胞分泌促卵泡激素（FSH）。组织学上，仅支持细胞在培养几天后仍保持正常。抑制素在下丘脑的作用在体外得到证实。促性腺激素释放激素（LHRH）的腺内含量与培养基中抑制素的含量呈负相关。在睾丸中，DNA合成依赖于抑制素。这在体内和体外对氚标记胸腺嘧啶核苷掺入睾丸DNA的研究中得到了证实。总之，抑制素由支持细胞产生，不仅作用于垂体水平，还作用于下丘脑和睾丸。
