Flye M W, Brennan M F
Ann Surg. 1981 Apr;193(4):425-35. doi: 10.1097/00000658-198104000-00006.
The incidence of parathyroid carcinoma is no more than 0.5 to 3% of parathyroid neoplasms and can often be cured by an adequate initial surgical excision. If the carcinoma has already spread outside the capsule or is implanted at surgery, the chance of local recurrence is high, but is best managed by surgical resection of any recurrence. Distant metastases occur less frequently, but the associated hypercalcemia is poorly controlled by hormonal, chemotherapy, or radiation therapy. Though the chance for cure is small, a review of previously reported cases and our own experience leads us to encourage an aggressive search for metastases, and if possible, surgical resection. If not curative, this approach will often allow prolonged palliation of the effect of hypercalcemia.
甲状旁腺癌的发病率不超过甲状旁腺肿瘤的0.5%至3%，通常可通过充分的初次手术切除治愈。如果癌已扩散至包膜外或在手术中种植，局部复发的几率很高，但最好通过手术切除任何复发病灶来处理。远处转移较少见，但相关的高钙血症通过激素、化疗或放疗难以控制。尽管治愈的机会很小，但回顾先前报道的病例及我们自己的经验后，我们鼓励积极寻找转移灶，若有可能，进行手术切除。如果无法治愈，这种方法通常能使高钙血症的影响得到长期缓解。
