Gonwa T A, Hamilton R W, Buckalew V M
Arch Intern Med. 1981 Mar;141(4):462-5.
A retrospective study was undertaken to determine the extent to which analgesic-associated nephropathy (AAN) causes chronic renal failure (CRF) and end-stage renal disease (ESRD). Of 363 cases of CRF diagnosed between 1974 and 1976, 48 were caused by AAN; 14 of 140 cases of ESRD were caused by AAN. Of the 14 patients with ESRD from AAN, 12 initially had ESRD and two progressed to ESRD while continuing consumption of analgesics. The remaining 34 patients who had AAN with CRF discontinued using analgesics and have not progressed to ESRD. Thus, 34 of 36 patients with AAN-CRF who initially did not have ESRD discontinued use of analgesics and have not progressed to ESRD. We conclude that AAN causes a large percentage of CRF and ESRD in our patient population. Early recognition of this entity can prevent progression to ESRD if analgesic consumption is discontinued.
进行了一项回顾性研究，以确定镇痛剂相关性肾病（AAN）导致慢性肾衰竭（CRF）和终末期肾病（ESRD）的程度。在1974年至1976年间诊断出的363例CRF病例中，48例由AAN引起；140例ESRD病例中有14例由AAN引起。在14例因AAN导致ESRD的患者中，12例最初就患有ESRD，2例在持续服用镇痛药期间进展为ESRD。其余34例患有AAN合并CRF的患者停止使用镇痛药，未进展为ESRD。因此，36例最初未患ESRD的AAN-CRF患者中有34例停止使用镇痛药，未进展为ESRD。我们得出结论，在我们的患者群体中，AAN导致了很大比例的CRF和ESRD。如果停止服用镇痛药，早期识别该疾病可预防进展为ESRD。
