Tamminga C A, Tighe P J, Chase T N, DeFraites E G, Schaffer M H
Arch Gen Psychiatry. 1981 Feb;38(2):167-8. doi: 10.1001/archpsyc.1981.01780270053006.
The beta-lipotrophin fragment des-tyrosine-gamma-endorphin (DT gamma E) has been reported to have antipsychotic properties. We administered the compound without other psychoactive drugs to a subpopulation of schizophrenic subjects. Male patients with chronic psychotic illness and previous long-term neuroleptic therapy were given DT gamma E at a similar dose and duration of treatment that have been reported to be effective. No improvement in psychotic symptoms occurred; plasma prolactin level, a parameter characteristically altered by neuroleptic treatment, did not change. The beneficial effects of DT gamma E in schizophrenia may be specific to a diagnostic category, may be dependent on past pharmacologic treatment, or may occur only in combination with other drugs.
据报道，β-促脂解素片段去酪氨酸-γ-内啡肽（DTγE）具有抗精神病特性。我们在未使用其他精神活性药物的情况下，将该化合物给予了一部分精神分裂症患者。患有慢性精神病且先前接受过长期抗精神病药物治疗的男性患者，接受了与已报道的有效剂量和治疗时长相似的DTγE治疗。精神病症状并未改善；血浆催乳素水平这一通常会因抗精神病药物治疗而改变的参数也未发生变化。DTγE对精神分裂症的有益作用可能特定于某一诊断类别，可能取决于既往的药物治疗，或者可能仅在与其他药物联合使用时才会出现。
