Giełdanowski J, Wieczorek Z, Kowalczyk-Bronisz S H, Kowalewska D, Błaszczyk B, Skibiński G, Zimecki M
Arch Immunol Ther Exp (Warsz). 1980;28(5):735-54.
The influence of l-nitro-9-/2-dihydroxyethylamino-ethylamino-/-acridine (C-835) and l-nitro-9/3-izopropylaminopropylamino/-acridine (C-846) on the basic functions of animal organism in acute and subchronic experiments was studied. Both compounds displayed distinct all-biologic activity. Their toxicity (LD50) in mice was contained in milligramme interval (i.v.), while LD50 administered into the stomach was several dozen times higher. Even administration in protective phosphate buffer, which provides the most neutral pH, produced quite strong local irritant action. The range between LD50 and LD10 was relatively small, which proved relatively small tolerance factor. Both preparations injected intravenously in the doses starting from several mg/kg had hypotensic influence due to their affinity with the myocardium, the parasymphatetic system and the vascular system. The preparations acted spasmolytically on intestine muscles both in vivo and in vitro in a number of animal species. Central action showed clear stimulating component in a behavioric test. The effect of the compounds in interaction to hypnotic and convulsant drugs was equivocal and dependent on the dose and the reference-preparation. The examined compounds did not influence reproduction processes and did not display the teratogenic action. They impaired only the speed of growth of the newborns. The effect of both examined compounds was qualitatively and quantitatively similar.
研究了1-硝基-9-（2-二羟乙基氨基-乙基氨基）-吖啶（C-835）和1-硝基-9-（3-异丙基氨基丙基氨基）-吖啶（C-846）在急性和亚慢性实验中对动物机体基本功能的影响。这两种化合物均表现出明显的全生物活性。它们在小鼠中的毒性（LD50）以毫克为单位（静脉注射），而经胃给药的LD50则高出几十倍。即使在提供最中性pH值的保护性磷酸盐缓冲液中给药，也会产生相当强烈的局部刺激作用。LD50和LD10之间的范围相对较小，这证明耐受性因子相对较小。从几毫克/千克开始静脉注射的两种制剂，由于它们与心肌、副交感神经系统和血管系统的亲和力，具有降压作用。在许多动物物种中，这些制剂在体内和体外对肠道肌肉都有解痉作用。在行为测试中，中枢作用显示出明显的刺激成分。这些化合物与催眠药和惊厥药相互作用的效果不明确，且取决于剂量和参比制剂。所检测的化合物不影响生殖过程，也不表现出致畸作用。它们仅损害新生儿的生长速度。所检测的两种化合物的作用在定性和定量上相似。
