类风湿因子与抗体/DNA复合物之间的相互作用：补体固定作用增强。
Interaction between rheumatoid factor and antibody/DNA complexes: enhancement of complement fixation.
作者信息
Birchmore D A, Taylor R P, Waller S J, Davis J S, Morley K W
出版信息
Arthritis Rheum. 1981 Mar;24(3):527-33. doi: 10.1002/art.1780240313.
PMID:7213431
Abstract
The influence of rheumatoid factor (RF) on the complement mediated binding of antibody/double-stranded DNA immune complexes to red blood cells has been investigated. Our results indicate that RF enhances this binding reaction, apparently by fixing complement via its own Fc region. These findings suggest that under certain circumstances, RF may play an exacerbating role in the antibody/DNA induced glomerulonephritis of systemic lupus erythematosus.
摘要
已经研究了类风湿因子（RF）对补体介导的抗体/双链DNA免疫复合物与红细胞结合的影响。我们的结果表明，RF增强了这种结合反应，显然是通过其自身的Fc区域固定补体来实现的。这些发现表明，在某些情况下，RF可能在系统性红斑狼疮的抗体/DNA诱导的肾小球肾炎中起加重作用。
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