[Effect of phenobarbital on hepatic glutathione and GSH-S transferase in the rat].

In the livers of rats treated with phenobarbital an increase of glutathione-S-transferase and glutathione is observed. The results suggest that phenobarbital could alter the disposition of certain toxic not only by increasing the rate of formation of less toxic metabolites, but also by increasing the amount of glutathione available for GSH-S-transferase that is involved in the formation of less toxic glutathione conjugates.