临床试验、综述及阴性结果杂志。
Clinical trials, reviews, and the Journal of Negative Results.
作者信息
Maxwell C
出版信息
Br J Clin Pharmacol. 1981 Jan;11(1):15-8. doi: 10.1111/j.1365-2125.1981.tb01095.x.
Abstract
1 Eighteen our of twenty non-significant placebo controlled trials are shown to have trends favouring imipramine and are consistent with a further ten significant at 0.05. 2 The problems of falsely positive and falsely negative results are discussed. A plea is made to medical journal editors to publish 'negative' or null difference trials by title only; rather than not at all.
摘要
- 20项无显著差异的安慰剂对照试验中有18项显示出有利于丙咪嗪的趋势，并且与另外10项在0.05水平有显著差异的试验结果一致。2. 讨论了假阳性和假阴性结果的问题。呼吁医学期刊编辑仅通过标题发表“阴性”或无差异的试验；而不是根本不发表。
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本文引用的文献
1
A statistical consideration in psychological research.心理学研究中的统计学考量。
Psychol Bull. 1951 May;48(3):156-8. doi: 10.1037/h0059111.
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Test of significance for a series of statistical tests.一系列统计检验的显著性检验。
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3
The speed of action of desipramine: a controlled trial.去甲丙咪嗪的起效速度：一项对照试验。
Int J Neuropsychiatry. 1967 Apr;3(2):140-1.
4
A statistical review of controlled trials of imipramine and placebo in the treatment of depressive illnesses.对丙咪嗪和安慰剂治疗抑郁症对照试验的统计综述。
Br J Psychiatry. 1975 Dec;127:599-603. doi: 10.1192/bjp.127.6.599.
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The importance of beta, the type II error and sample size in the design and interpretation of the randomized control trial. Survey of 71 "negative" trials.β错误、II型错误以及样本量在随机对照试验设计与解读中的重要性。对71项“阴性”试验的调查。
N Engl J Med. 1978 Sep 28;299(13):690-4. doi: 10.1056/NEJM197809282991304.
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