肼屈嗪、二氮嗪、亚硝酸钠和硝普钠对人体离体动脉和静脉作用的比较。
A comparison of the effects of hydrallazine, diazoxide, sodium nitrite and sodium nitroprusside on human isolated arteries and veins.
作者信息
Moulds R F, Jauernig R A, Shaw J
出版信息
Br J Clin Pharmacol. 1981 Jan;11(1):57-61. doi: 10.1111/j.1365-2125.1981.tb01102.x.
1 Human common palmar digital arteries and dorsal metacarpal veins have been studied in vitro to investigate the responses of arterial and venous muscle to hydrallazine, diazoxide, nitroprusside and sodium nitrite. 2 Tissues were removed at autopsy, cut into helical strips and suspended in organ baths under identical conditions. The contractile response to noradrenaline was tested in the presence of the same concentrations of the vasodilator drugs in arteries and veins. 3 Hydrallazine antagonised contraction of arteries, but not veins to noradrenaline. Diazoxide, nitroprusside or sodium nitrite antagonised responses in both arteries and veins. Diazoxide and nitrite were more effective on arteries and nitroprusside was more effective on veins. 4 These results are in accord with clinical observations and confirm that there are differences in the susceptibility of human arterial and venous smooth muscle to vasorelaxant drugs.
1 对人体掌侧指总动脉和手背静脉进行了体外研究，以调查动脉和静脉平滑肌对肼屈嗪、二氮嗪、硝普钠和亚硝酸钠的反应。2 在尸检时取出组织，切成螺旋条，并在相同条件下悬于器官浴槽中。在动脉和静脉中存在相同浓度血管扩张药物的情况下，测试对去甲肾上腺素的收缩反应。3 肼屈嗪可拮抗动脉而非静脉对去甲肾上腺素的收缩作用。二氮嗪、硝普钠或亚硝酸钠可拮抗动脉和静脉中的反应。二氮嗪和亚硝酸盐对动脉更有效，硝普钠对静脉更有效。4 这些结果与临床观察结果一致，并证实人体动脉和静脉平滑肌对血管舒张药物的敏感性存在差异。
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