去除内皮可增强硝普钠和亚硝酸钠引起的血管舒张作用。
Endothelium removal augments vasodilation by sodium nitroprusside and sodium nitrite.
作者信息
Shirasaki Y, Su C
出版信息
Eur J Pharmacol. 1985 Aug 7;114(1):93-6. doi: 10.1016/0014-2999(85)90527-8.
PMID:4043223
Abstract
Sodium nitroprusside (3-100 nM) and sodium nitrite (0.03-1 mM) caused relaxation of the rat aortic ring segments precontracted by norepinephrine. The relaxation was significantly augmented by removal of endothelium, and this augmentation was greater in the aorta from spontaneously hypertensive rats (SHR) than Wistar Kyoto rats (WKY). The mechanism remains unknown but such augmentation may be clinically favorable to the use of nitrovasodilators.
摘要
硝普钠（3 - 100 nM）和亚硝酸钠（0.03 - 1 mM）可使去甲肾上腺素预收缩的大鼠主动脉环段舒张。去除内皮后，舒张作用显著增强，且自发性高血压大鼠（SHR）主动脉的这种增强作用比Wistar Kyoto大鼠（WKY）更大。其机制尚不清楚，但这种增强作用在临床上可能有利于硝基血管扩张剂的使用。
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