[Structure of gangliosides of normal and leukemic bovine blood lymphocytes].

The structure of main gangliosides from normal and leukemic bovine blood lymphocytes was established. N-Glycoloylhematoside and a ganglioside containing N-glycoloylneuraminic acid and an oligosaccharide chain identical to that of erythrocyte sialosylparagloboside were found to be present both in normal and in leukemic bovine blood lymphocytes. In addition, the leukemic lymphocytes contained a ganglioside identical to N-acetylneuraminosylparagloboside and at least two disialosyllactosylceramides containing N-acetyl- and N-glycoloylneuraminic acids. It was assumed that lymphocyte maturation is accompanied by a loss of disialosyllactosylceramide and that the latter influences the immunological properties of the apparently less mature leukemic peripheral lymphocytes.