Trapeznikova S S, Lapteva I V, Kozlova M A
Biokhimiia. 1980 Jun;45(6):1080-5.
The binding of the biologically active bradikinin analog--[125I]-tyr-B to partially purified fractions of plasma membranes from rat and rabbit aorta and from human umbilical veins and arteries has been studied. It was shown that some regions of vascular plasma membranes have a high affinity for the analog (Kac = 2--6.10(8) M-1). The capacity for competitive substitution of angiotensin II and [125I]-angiotensin II-tyr-B for [125I]-tyr-B suggests the similarity of the binding sites of plasma membranes of the two biologically active peptides--bradikinin and angiotensin II.
已对生物活性缓激肽类似物——[125I]-酪氨酰-B与来自大鼠和兔主动脉以及人脐静脉和动脉的部分纯化质膜组分的结合进行了研究。结果表明，血管质膜的某些区域对该类似物具有高亲和力（Kac = 2 - 6×10⁸ M⁻¹）。血管紧张素II和[125I]-血管紧张素II-酪氨酰-B对[125I]-酪氨酰-B的竞争性取代能力表明，两种生物活性肽——缓激肽和血管紧张素II的质膜结合位点具有相似性。
