[Nature of the relation between the anticonvulsant action of phenazepam and its concentration in mouse brain].

A method has been suggested for simultaneous recording of the content of 12C-phenazepam and its metabolites in the mouse brain and of minimum effective doses of corasole intravenously that induce the tonic extension of the animals. Parameters of the two-compartmental kinetic model of absorption, distribution and elimination of 14C-products in the mouse brain were determined. These processes conform to the first order kinetics. A correlation was disclosed between the content of radioactive products in the animals' brain and minimum effective doses of corasole. A linear decline of the anticonvulsant action of phenazepam was revealed during the experimental period. Radiochromatography enabled one to detect the parent compound and its 3-hydroxy metabolite in mouse brain extracts.