[Biotransformation of the 14C-hydrogenated analog of phenazepam in inbred mice].

The elimination of 14C-hydrogenated analogue of phenazepam and its metabolites was studied in inbred C57B1/6 (B/6), BALB-c (C) and CBA mice. The kinetics of two-phase elimination of 14C-compounds with urine and feces was similar in all the above mouse strains. The excretion was realized mainly with feces, exceeding elimination with urine 5-6-fold in B6 mice and 10-11-fold in C and CBA mice. Some interstrain quantitative differences in metabolite composition were found. No metabolite was detected whose concentration would indicate a predominating direction of biotransformation of 14C-hydrogenated phenazepam analogue or distinguish it from other mouse strains. In the organism of mice, 14C-hydrogenated phenazepam analogue undergoes active aromatic hydroxylation and methoxylation via heterocycle (and possibly via chlorine-containing ring). At the same time dehydrogenation of 14C-hydrogenated phenazepam analogue molecule was not recorded.