Rattanapanone V, Tashiro S, Tokuda H, Rattanapanone N, Ito Y
Cancer Res. 1981 Apr;41(4):1483-7.
Cellular retinoic acid-binding protein (cRABP) was detected in the cytosol of virus-induced papilloma (Shope) of rabbit skin. The Shope papilloma cRABP showed the same ligand specificity and sedimentation value (2S) as was found in other animal species. The level of cRABP in the papillomatous tissue was significantly higher than that in the normal rabbit skin and increased in accordance with the growth and development of the tumor, reaching a peak about 40 days after the inoculation of the Shope papilloma virus. Although this binding capacity was about 15 times greater than in the normal skin, the level of cRABP in the transplantable carcinomas Vx2 and Vx7, both originating from the virus-induced papillomas over 20 years ago, was much the same as in normal rabbit skin.
在兔皮肤病毒诱导的乳头瘤（肖普乳头瘤）的细胞质中检测到细胞视黄酸结合蛋白（cRABP）。肖普乳头瘤cRABP表现出与其他动物物种相同的配体特异性和沉降值（2S）。乳头瘤组织中cRABP的水平显著高于正常兔皮肤，且随着肿瘤的生长和发育而增加，在接种肖普乳头瘤病毒后约40天达到峰值。尽管这种结合能力比正常皮肤大15倍左右，但源自20多年前病毒诱导乳头瘤的可移植癌Vx2和Vx7中的cRABP水平与正常兔皮肤中的水平大致相同。
