Huber P R, Geyer E, Küng W, Matter A, Torhorst J, Eppenberger U
J Natl Cancer Inst. 1978 Dec;61(6):1375-8.
Seventy-five specimens of human breast tissue were checked for the presence of cellular retinoic acid-binding protein (cRABP). Fifty-two percent of the primary carcinomas and 43% of the dysplastic breast lesions (stage MII) contained detectable amounts of crabp, whereas no cRABP was found in normal tissue. Sucrose gradient centrifugation and electrophoresis on agarose were used for analysis of the presence of cRABP. The cRABP of human origin (normal uterus and neoplastic mammary tissue) differed in its mobility in agarose electrophoresis from that of rat testis cRABP.
对75份人类乳腺组织样本进行了细胞视黄酸结合蛋白（cRABP）检测。52%的原发性癌和43%的发育异常乳腺病变（MII期）含有可检测量的crabp，而在正常组织中未发现cRABP。采用蔗糖梯度离心和琼脂糖电泳分析cRABP的存在情况。人类来源（正常子宫和肿瘤性乳腺组织）的cRABP在琼脂糖电泳中的迁移率与大鼠睾丸cRABP不同。
