Okabe-Kado J, Honma Y, Hayashi M, Hozumi M
Cancer Res. 1981 May;41(5):1997-2002.
Mouse myeloid leukemic cells (M1) could be induced to differentiate into macrophage-like and granulocyte-like cells by a lysine-rich, histone H1 fraction (10 to 100 microgram/ml). The differentiated M1 cells expressed phagocytic and lysozyme activity and were macrophage-like and granulocyte-like cells. The differentiation-inducing activity of histone H1 was found in histone H1 fractions isolated from calf thymus, rat liver, and mouse leukemia M1 cells. Histone H2A and H2B fractions did not induce differentiation of M1 cells at concentrations of 10 to 100 microgram/ml but did induce differentiation at a high concentration (200 microgram/ml). The histone H3 fraction, poly-L-lysine and poly-L-arginine, inhibited induction of differentiation of M1 cells.
富含赖氨酸的组蛋白H1组分（10至100微克/毫升）可诱导小鼠髓系白血病细胞（M1）分化为巨噬细胞样和粒细胞样细胞。分化后的M1细胞表现出吞噬活性和溶菌酶活性，属于巨噬细胞样和粒细胞样细胞。从小牛胸腺、大鼠肝脏和小鼠白血病M1细胞中分离得到的组蛋白H1组分均具有诱导分化活性。组蛋白H2A和H2B组分在10至100微克/毫升浓度下不能诱导M1细胞分化，但在高浓度（200微克/毫升）时可诱导分化。组蛋白H3组分、聚-L-赖氨酸和聚-L-精氨酸可抑制M1细胞的分化诱导。
