Sochor M, McLean P, Brown J, Greenbaum A L
Enzyme. 1981;26(1):15-23.
There is a significant increase in four of the urea cycle enzymes in liver from hypothyroid rats, arginase alone showed an opposite trend; these changes are reversed by physiological doses of thyroxine; hyperthyroidism results in a significant decrease in ornithine transcarbamoylase activity. The pattern of change in thyroidectomized and alloxan-diabetic rats showed marked similarities in respect to urea cycle and ornithine-metabolizing enzymes which are discussed in the light of the common feature of hypoinsulinism of diabetes and depressed response to insulin in hypothyroidism. The profile of ornithine-metabolizing enzymes is consonant with the decreased protein synthesis and turnover in hypothyroidism.
甲状腺功能减退大鼠肝脏中的四种尿素循环酶显著增加，仅精氨酸酶呈现相反趋势；这些变化可被生理剂量的甲状腺素逆转；甲状腺功能亢进导致鸟氨酸转氨甲酰酶活性显著降低。甲状腺切除和四氧嘧啶糖尿病大鼠的变化模式在尿素循环和鸟氨酸代谢酶方面表现出明显的相似性，鉴于糖尿病的低胰岛素血症和甲状腺功能减退对胰岛素反应降低的共同特征进行了讨论。鸟氨酸代谢酶的概况与甲状腺功能减退时蛋白质合成和周转减少一致。
