Papachristou D N, Claudatou D, Fortner J G
Eur Surg Res. 1980;12(5):310-6. doi: 10.1159/000128136.
Ligation of the intact horizontal segment of the pancreas in 8 dogs caused enlargement and then atrophy of the gland. Ligation of dissected pancreases in 9 dogs caused pseudocysts, fistulae and pancreatic ascites in 6. Ligation following obliteration of the ductal system with cyanoacrylate tissue adhesive in 8 dissected pancreases caused no pancreatic complications. Both ligation and obliteration reduced the glucose consumption coefficient (k-value) below the preoperative levels (p less than 0.01), there was no difference, however, between the two methods as far as glucose consumption is concerned. Ductal obliteration might prevent the development of pancreatic fistulae following the Whipple procedure offering an alternative to either simple ligation or pancreatojejunostomy.
对8只狗的完整胰腺水平段进行结扎，导致胰腺肿大，随后萎缩。对9只狗的解剖胰腺进行结扎，6只出现了假性囊肿、瘘管和胰性腹水。对8只解剖胰腺用氰基丙烯酸酯组织粘合剂闭塞导管系统后进行结扎，未出现胰腺并发症。结扎和闭塞均使葡萄糖消耗系数（k值）降至术前水平以下（p<0.01），然而，就葡萄糖消耗而言，两种方法之间没有差异。导管闭塞可能会防止惠普尔手术后胰瘘的发生，为单纯结扎或胰空肠吻合术提供了一种替代方法。
