大鼠急性窦神经-主动脉神经去神经支配可导致延髓尾端背中线区域肾上腺素周转选择性增加，以及下丘脑前后部肾上腺素水平降低。
Acute sino-aortic denervation in rats produces a selective increase of adrenaline turnover in the dorsal midline area of the caudal medulla oblongata and a reduction of adrenaline levels in the anterior and posterior hypothalamus.
作者信息
Yukimura T, Fuxe K, Ganten D, Andersson K, Härfstrand A, Unger T, Agnati L F
出版信息
Eur J Pharmacol. 1981 Jan 29;69(3):361-5. doi: 10.1016/0014-2999(81)90484-2.
PMID:7215433
Abstract
Acute sino-aortic denervation produces an acute reduction of adrenaline stores in the anterior and posterior hypothalamus and a reduction of noradrenaline stores in the dorsal midline area of the caudal medulla oblongata. Furthermore, removal of baroreflex afferents results in an increase of adrenaline turnover in the DCMO but not in the hypothalamus. The present findings give evidence for participation of adrenergic mechanisms in central baroreflex regulation. The findings can be interpreted according to the adrenaline vasodepressor hypothesis of hypertension.
摘要
急性窦主动脉去神经支配会导致下丘脑前后部肾上腺素储备急性减少，以及延髓尾端背中线区域去甲肾上腺素储备减少。此外，去除压力反射传入神经会导致延髓尾端背中线区域肾上腺素周转率增加，但下丘脑则不会。目前的研究结果为肾上腺素能机制参与中枢压力反射调节提供了证据。这些结果可根据高血压的肾上腺素血管减压假说进行解释。
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